Journal of PharmaSciTech Role of Ascorbic Acid on Gentamicin Induced Alteration in Plasma Lipid Profile

The term plasma lipid profile considers measurement of certain components of plasma including total cholesterol (TCh), high density lipoprotein cholesterol (HDL-Ch), triglycerides (Tg), low density blipoprotein cholesterol (LDL-Ch) and very low density lipoprotein cholesterol (VLDL-Ch). TCh consists of all the cholesterol present in different lipoproteins like high density lipoprotein (HDL), low density lipoprotein (LDL), and very low density lipoprotein (VLDL). HDL-Ch is believed to play a vital role in the removal of excess cholesterol from the blood vessel wall to the liver for excretion [1-2]. On the other hand, LDL-Ch (high cholesterol content) is responsible for the deposition of cholesterol in the inner wall of the artery, resulting in atherosclerosis. The neutral fat Tg are found in the tissue and blood. Adipose tissue is the main store house of calories and comprises of Tg. The large group of macromolecule VLDL-Ch is synthesized and secreted mainly by liver and intestinal mucosal cells, and contain large proprtion of Tg [3]. Tg may also have a role in the development of coronary heart disease (CHD) [4].